Eat less move more. Eat less and move more. If you reduce your intake by 500 calories a day, you can lose a pound a week. If you increase your daily activity, that increases your metabolism and helps you to lose weight.
Diet and exercise. There's no great medical secret here. It's all about burning more calories than you take in. Use a daily food diary to track your food intake ("mynetdiary" smartphone app works great). Try to get 30-45 minutes of non-stop aerobic exercise everyday. Eat more whole grains and avoid the "white stuff" (white pasta, bread, potatos). Your goal is 1-2 lbs a week, no more. Be patient & dont give up.
Increase activity. For most people, adding moderate exercise such as a daily 30 minute walk will result in slow, sustainable weight loss. Along with this, try to eliminate high-calorie beverages and substitute water. This combination often results in a difference of 500 calories daily, which adds up to a pound a week.