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I've seen metformin as having weigh loss and weight gain listed as side effect. Might certain health conditions predispose me for one or the other?

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Dr. Dan Fisher
Internal Medicine

In brief: Maybe.

Metformin usually induces modest wt loss of a few lbs.
I have never seen anyone gain weight. The mechanism for wt loss is debated- might be related to decreased circulating Insulin levels but may also be due to direct GI irritation / stimulation ( nausea or diarrhea). Any underlying GI disease or "sensitive" gut might predispose you to weight loss.

In brief: Maybe.

Metformin usually induces modest wt loss of a few lbs.
I have never seen anyone gain weight. The mechanism for wt loss is debated- might be related to decreased circulating Insulin levels but may also be due to direct GI irritation / stimulation ( nausea or diarrhea). Any underlying GI disease or "sensitive" gut might predispose you to weight loss.
Dr. Dan Fisher
Dr. Dan Fisher
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