What is an autologous bone marrow transplant and when is it used?

High dose chemo. This is a treatment that uses very high doses of chemotherapy and/or radiation to treat cancers. The doses are so high that the normal bone marrow is destroyed. The patient's own bone marrow or stem cells are then reinfused to allow the bone marrow to recover. It is used for certain cancers and some autoimmune diseases.
5 kind of Bone M T. Autologous transplant—transplanted cells come from the body of the transplant recipient. Allogeneic transplant—transplanted cells come from a donor who may be related to the recipient (a family member) or unrelated. The advantage to using the child’s own stem cells is that he or she will not face the complications of graft-versus-host disease. However, with an autologous transplant the child does.

Related Questions

What is a autologous bone marrow transplant?

Autologous transpant. When patient own cells are infused back to patient. Read more...
Stem cell transplant. An autologous bone marrow or stem cell transplant involves giving a patient high doses of chemotherapy followed by infusion of their own bone marrow or blood stem cells. It is a treatment generally used to treat certain blood cancers. Rarely it is used for certain solid tumors. There are clinical trials evaluating the role of these transplants for certain autoimmune disorders too. Read more...
The patient is donor. In case of myeloma certain lymphomas in general patients receive chemotherapy , achieve a response and then have stem cells mobilized from their marrow- frozen- patient goes through high doses of chemo to clear the marrow or kill as many tumor cells as possible and then reinfuse cells back. The idea is that high doses of chemotherapy can cause prolong remission or cure. Read more...

How long does the autologous bone marrow transplantation take?

About 4-6 weeks. There are 2 steps- the first is to collect your stem cells which usually is a 5-15 day process. Then the next step is the transplant phase which usually involves about a week of therapy, then getting your own saved cells thawed and infused back to you like a blood transfusion (over an hour for instance), then 2-4 weeks of recovery. Read more...

What does a patient go through before having a bone marrow transplant. And after the transplant?

It's complicated. There are different protoclos but generally it starts with drugs to supress or destroy recipient bone marrow, and drugs to block the immune system so the graft can "take". Blood counts are low, and infections occur, transfusions needed. Once engrafted, worry is graft vs host disease and powerful immunosupressive drugs are given to prevent or treat gvhd. Sites are lung, liver, skin, GI tract. Read more...

What do you suggest if my brother has hodgkins lymphoma and he had a bone marrow transplant and got gvhd, what will happen now?

Immune reaction. Graft versus host disease (GvHD) occurs following an allogeneic bone marrow transplant where donated marrow cells view your brothers body as foreign, and attack his body. A Factor that increase acute GvHD, is the HLA match, which causes donor cells to recognize recipient cells as foreign, leading to an immune response.This causes an increased risk of infection, rash etc treated with steroids. Read more...
Depends on severity . Low grade of gvhd may not be that bad in terms of prognosis. It may actually signify graft vs lymphoma affect. Poorly controlled high grade of gvhd is not good. Read more...