What does a bone marrow transplant do for sickle cell?

Replacing RBCs. Sickle cell disease is caused by a person producing faulty red blood cells (rbcs). Since all blood cells are produced in the bone marrow, a bone marrow transplant from a healthy donor should be able to replace the faulty bone marrow with healthy bone marrow that is able to produce normal red blood cells. However, this is not a common treatment so its clinical efficacy is not well-established.
Fixes the problem. The bone marrow transplant replaces the bone marrow stem cells with new stem cells from the donor that make normal red blood cells. By getting rid of the sickle red blood cells the sickle cell anemia is fixed. But, this is a very serious procedure with many risks and side effects that must be weighed before using this therapy.

Related Questions

My daughter has sickle cell anemia we tested for bone marrow transplant no matches is there anything else that might cure my daughter?

Bone Marrow transpl. Ask your church community to host a blood drive and encourage people to be swabbed for the bone marrow transplant data base. Cure of ss is only by marrow transplant. If more people are in the registry, you may find a match. Read more...
I agree. I agree with Dr. Keimowitz's response. In order to expand the Bone Marrow Donor pool for you, you need to host a donor drive which you can do in your community. Read more...

Sickle cell disease - is it curable with a bone marrow transplant?

Yes but... A bone marrow transplant can cure sickle cell disease but the procedure has many serious risks and side effects. Talk with a hematologist about this option. Read more...
I do not know. Most patients with sickle cell diseaes have a very benign manifestation of the diseas (trait) and they can live close to a normal life. E few percentage of this people has severe disease. I do not have experience with bone marrow transplant for sickle cell disease. Read more...

Sickle cell disease bone marrow transplant. Is that working out or not?

No clear results. There is not level 1 evidence to show bone marrow transplant increases survival in patients with sickle cell disease. Although there are several reports with success a systematic randomized trial remains to be done. Bone marrow transplant is a procedure with multiple complications. After the procedure the recipient has to take meds for life. Cost/effective therapy analyses are not present. Read more...
For select patients. Bone marrow transplant can cure patients with sickle cell disease, however this procedure has significant risks (including death). There is emerging evidence that the earlier one is transplanted for sickle cell disease, the better the outcome. This is a difficult decision to make since many with sickle cell have mild disease. Deciding who should be transplanted and when is not straight forward. Read more...

How good is the bone marrow transplant for a sickle cell patient?

Very! If a patient with sickle cell disease has a well-matched donor and gets through the transplant procedure safely with good engraftment of the donor bone marrow, they will be converted to normal or sickle trait depending on the donor. Read more...

How often does a bone marrow transplant not work, and the leukemia cells come back?

Please give more inf. Depends on many factors including the type of leukemia, age, type of transplant. A more specific question would be easier to give an adequate response. In general allogeneic transplants for AML in remission usually have a leukemia free relapse rate of greater than 50%. Read more...
Variable. The success and failure rate of a bone marrow transplant is dependent on factors such as the type of leukemia, prior therapies the patient has had, type of transplant, and the number of times the leukemia has relapsed in the past. Please ask the question again with more details. Read more...
Depends,.... The specific leukemia, remission status at transplant, chemo/radiation used to do the transplant etc all must be considered to provide more information on this issue. Read more...

Could stem cells prevent need for a bone marrow transplant?

NO. Bone marrow transplant is a stem cell procedure. This can be your own bone marrow stem cells, a family member or match for bone marrow or embryonic stem cells. Read more...

Can stem cells prevent the future need for a bone marrow transplant?

They are the same. When someone gets a bone marrow transplant (also called a stem cell transplant) what they are given from their donor are hematopoietic (blood forming) stem cells. So getting stem cells is what happens during a bone marrow/stem cell transplant. Read more...

Can stem cells be used as a substitute for a bone marrow transplant?

Let me clarify. Stem cells are the mother cells. For blood formation the stem cells reside in the bone marrow but they also circulate in the blood. In the old days we took the stem cells out of the bone marrow with needles. Now we can spin the blood(from a vein) and take th stem cells out and use them for transplants to make new blood. This is stricly for creating new blood cells. But each organ has its stem cell. Read more...