2 doctors weighed in:

What's the difference between primary and secondary addison's disease?

2 doctors weighed in
Dr. Al Hegab
Internal Medicine - Allergy & Immunology

In brief: 1ry starts in gland

Primary addison's originates in the adrenal gland for diverse reasons, autoimmune (self destruction by auto antibodies) or after an infection (e.
G tb), invasion by cancer or hemorrhage into the gland, while in the secondary type the gland itself is healthy but the pituitary gland (the maestro of endocrine glands) isn't working so other endocrine glands won't function probably.

In brief: 1ry starts in gland

Primary addison's originates in the adrenal gland for diverse reasons, autoimmune (self destruction by auto antibodies) or after an infection (e.
G tb), invasion by cancer or hemorrhage into the gland, while in the secondary type the gland itself is healthy but the pituitary gland (the maestro of endocrine glands) isn't working so other endocrine glands won't function probably.
Dr. Al Hegab
Dr. Al Hegab
Thank
Dr. Soumya Adhikari
Pediatrics - Endocrinology

In brief: Source of problem

Addison's disease is a failure of your adrenal glands to make the hormones they usually make.
In primary disease it is the adrenals themselves that are problematic, whereas in secondary disease it is the pituitary gland, which produces a signal which stimates (desmopressin) the adrenals to do what they do, that is the source of the problem. The hormones likely to be deficient can be very different in the two.

In brief: Source of problem

Addison's disease is a failure of your adrenal glands to make the hormones they usually make.
In primary disease it is the adrenals themselves that are problematic, whereas in secondary disease it is the pituitary gland, which produces a signal which stimates (desmopressin) the adrenals to do what they do, that is the source of the problem. The hormones likely to be deficient can be very different in the two.
Dr. Soumya Adhikari
Dr. Soumya Adhikari
Thank
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