3 doctors weighed in:

Is it safe to take Benadryl (diphenhydramine) and melatonin?

3 doctors weighed in
Dr. Ralph Morgan Lewis
Family Medicine
2 doctors agree

In brief: With caution

Although technically no drug-drug interactions are listed for the 2, both cause sedation & might have an additive effect.
Be sure how the combination will affect you before operating machinery or driving. People have been cited for dui from Benadryl (diphenhydramine) alone.

In brief: With caution

Although technically no drug-drug interactions are listed for the 2, both cause sedation & might have an additive effect.
Be sure how the combination will affect you before operating machinery or driving. People have been cited for dui from Benadryl (diphenhydramine) alone.
Dr. Ralph Morgan Lewis
Dr. Ralph Morgan Lewis
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