6 doctors weighed in:

What are the chances of inheriting cystic fibrosis if one parent has trait?

6 doctors weighed in
Dr. James Ferguson
Pediatrics
1 doctor agrees

In brief: Depends

This depends on the profile of the other parent.
Their are dozens of mutations that can lead to CF, although most are the delta 509. Both parents must carry a CF related gene for an offspring to get it, and if so the risk is 25%. Carrier testing is available through specialty labs.If only one has trait ,zero.

In brief: Depends

This depends on the profile of the other parent.
Their are dozens of mutations that can lead to CF, although most are the delta 509. Both parents must carry a CF related gene for an offspring to get it, and if so the risk is 25%. Carrier testing is available through specialty labs.If only one has trait ,zero.
Dr. James Ferguson
Dr. James Ferguson
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Dr. William Walsh
Addiction Medicine
1 doctor agrees

In brief: Close to zero

CF is autosomal recessive, you need to inherit a defective copy of the gene from each parent.
Baring spontaneous mutation or some similarly rare event, both parents need to have the gene to inherit the disease.

In brief: Close to zero

CF is autosomal recessive, you need to inherit a defective copy of the gene from each parent.
Baring spontaneous mutation or some similarly rare event, both parents need to have the gene to inherit the disease.
Dr. William Walsh
Dr. William Walsh
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David Escobar
Family Medicine
1 doctor agrees

In brief: Zero

In order for any possibility of a child acquiring cystic fibrosis (cf), both biological parents would have to have the CF trait as carriers.
CF is known as an autosomal recessive disease, which means both parents have to be carriers in order for their child to possibly acquire the disease. In these cases, when both parents are carriers, there is a 25% chance the child will acquire cf.

In brief: Zero

In order for any possibility of a child acquiring cystic fibrosis (cf), both biological parents would have to have the CF trait as carriers.
CF is known as an autosomal recessive disease, which means both parents have to be carriers in order for their child to possibly acquire the disease. In these cases, when both parents are carriers, there is a 25% chance the child will acquire cf.
David Escobar
David Escobar
Answer assisted by David Escobar, Medical Student
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