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How does HIV cause polyclonal cell activation?
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Dr. Ed Friedlander
Pathology
In brief: B-cells
The ways in which HIV and hiv-infected immune cells cause overgrowth of uninfected b-cells, making them divide (polyclonal) and overfunction (polyclonal gammopathy, b-cell quasi-lymphomas) are coming to be known and are hugely complex.
Best recent review http://www.Nature.Com/nri/journal/v9/n4/execsumm/nri2524.Html.

In brief: B-cells
The ways in which HIV and hiv-infected immune cells cause overgrowth of uninfected b-cells, making them divide (polyclonal) and overfunction (polyclonal gammopathy, b-cell quasi-lymphomas) are coming to be known and are hugely complex.
Best recent review http://www.Nature.Com/nri/journal/v9/n4/execsumm/nri2524.Html.
Dr. Ed Friedlander
Dr. Ed Friedlander
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