How does HIV cause polyclonal cell activation?

B-cells. The ways in which HIV and hiv-infected immune cells cause overgrowth of uninfected b-cells, making them divide (polyclonal) and overfunction (polyclonal gammopathy, b-cell quasi-lymphomas) are coming to be known and are hugely complex. Best recent review http://www.Nature.Com/nri/journal/v9/n4/execsumm/nri2524.Html.