4 doctors weighed in:
What does small m protein and IgG lambda spike mean?
4 doctors weighed in

Dr. Michael P Vaughn
Internal Medicine - Allergy & Immunology
3 doctors agree
In brief: Monoclonal M-spikes
Antibodies such as igg are usually polyclonal.
This means that many different b-cells are making antibodty with many different binding specificities. Monoclonal (m-spikes) suggest that the origin of the antibody is from one clone of blood cells, all originating from a sinle progenitor. This could mean a pre-malignant or malignant populations of cell are present.

In brief: Monoclonal M-spikes
Antibodies such as igg are usually polyclonal.
This means that many different b-cells are making antibodty with many different binding specificities. Monoclonal (m-spikes) suggest that the origin of the antibody is from one clone of blood cells, all originating from a sinle progenitor. This could mean a pre-malignant or malignant populations of cell are present.
Dr. Michael P Vaughn
Dr. Michael P Vaughn
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