What is the significance of spleen in relation to immunology?

Spleen . In the absemce of the spleen, most infection is handled normally but a risk of severe infection with pneumococcus exists depending on the reason for spleen removal and the time after it.
Major player. Your spleen is an integral part of your immune system. It protects you from certain kind of infection, helps eliminate used up red blood cell, acting like the biggest lymph node in your body. However, it is not considered a vital organ and you can be healthy without it. Some people lose their spleens in auto accident, some needed splenectomy when it is dysfunctional.