4 doctors weighed in:
What alpha fetoprotein level would suggest hepatocellular carcinoma?
4 doctors weighed in

1 doctor agrees
In brief: Alfa feto protein
Normally in the upper hundreds or thousands as i recall.

In brief: Alfa feto protein
Normally in the upper hundreds or thousands as i recall.
Dr. Juan Peschiera
Dr. Juan Peschiera
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Dr. Mary Maluccio
Surgery - Oncology
In brief: Depends
AFP is not particularly sensitive as it can be elevated in patients with viral hepatitis and no cancer and normal in patients with cancer. We use a cut off of approximately 200 to raise suspicion for hcc in patients with liver disease.
In patients with a lesion in the liver and no underlying liver disease, any elevation in AFP above normal would likely be hcc.

In brief: Depends
AFP is not particularly sensitive as it can be elevated in patients with viral hepatitis and no cancer and normal in patients with cancer. We use a cut off of approximately 200 to raise suspicion for hcc in patients with liver disease.
In patients with a lesion in the liver and no underlying liver disease, any elevation in AFP above normal would likely be hcc.
Dr. Mary Maluccio
Dr. Mary Maluccio
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1 comment
Dr. Myron Schwartz
The above applies primarily in patients with hepatitis C; with other underlying diseases AFP is much more specific for HCC. In any case, the trend can be more important than the absolute value; when every value is higher than the last HCC is highly likely whereas fluctuating values suggest hepatitis as the cause.
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