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Rh incompatibility in second pregnancy; how does it happen?
1 doctor weighed in

Dr. James Ball
Pediatrics - Hematology & Oncology
In brief: Sensitization
Mom is rh negative.
Dad is rh positive. The baby, possibly both, are also rh positive. The first pregnancy will sensitize mom causing her to produce an rh antibody. This antibody will decrease over time. But with a second pregnancy, the memory cells cause tremendous antibody production. This antibody crosses through placenta and breakdown the red blood cells of the infant.

In brief: Sensitization
Mom is rh negative.
Dad is rh positive. The baby, possibly both, are also rh positive. The first pregnancy will sensitize mom causing her to produce an rh antibody. This antibody will decrease over time. But with a second pregnancy, the memory cells cause tremendous antibody production. This antibody crosses through placenta and breakdown the red blood cells of the infant.
Dr. James Ball
Dr. James Ball
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