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Rh incompatibility in second pregnancy; how does it happen?

1 doctor weighed in
Dr. James Ball
Pediatrics - Hematology & Oncology

In brief: Sensitization

Mom is rh negative.
Dad is rh positive. The baby, possibly both, are also rh positive. The first pregnancy will sensitize mom causing her to produce an rh antibody. This antibody will decrease over time. But with a second pregnancy, the memory cells cause tremendous antibody production. This antibody crosses through placenta and breakdown the red blood cells of the infant.

In brief: Sensitization

Mom is rh negative.
Dad is rh positive. The baby, possibly both, are also rh positive. The first pregnancy will sensitize mom causing her to produce an rh antibody. This antibody will decrease over time. But with a second pregnancy, the memory cells cause tremendous antibody production. This antibody crosses through placenta and breakdown the red blood cells of the infant.
Dr. James Ball
Dr. James Ball
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