3 doctors weighed in:
What happens to the insulin receptors to make them insulin resistant?
3 doctors weighed in

Dr. Richard Shewbridge
Internal Medicine - Endocrinology
2 doctors agree
In brief: Great question!
If you figure that one out, you will probably win the nobel prize in medicine.
There are easily over 100 different defects in Insulin signaling (how Insulin talks to cells) which have been described in type 2 diabetic patients, ranging from mild to severe. That's one of the reasons why coming up with a cure for this disease is so difficult.

In brief: Great question!
If you figure that one out, you will probably win the nobel prize in medicine.
There are easily over 100 different defects in Insulin signaling (how Insulin talks to cells) which have been described in type 2 diabetic patients, ranging from mild to severe. That's one of the reasons why coming up with a cure for this disease is so difficult.
Dr. Richard Shewbridge
Dr. Richard Shewbridge
Thank
Dr. Gutti Rao
Internal Medicine - Hospital-based practice
In brief: Insulin receptors
In type 2 diabetes mellitus, there is a down regulation ( less number) of Insulin receptors otherwise called adiponectin receptors.
Increasing Insulin administration may not help as Insulin has to attach itself to these receptors on the cell membrane. Medication class called tzd up regulates these receptors helping circulating Insulin to attach to the cells for its action.

In brief: Insulin receptors
In type 2 diabetes mellitus, there is a down regulation ( less number) of Insulin receptors otherwise called adiponectin receptors.
Increasing Insulin administration may not help as Insulin has to attach itself to these receptors on the cell membrane. Medication class called tzd up regulates these receptors helping circulating Insulin to attach to the cells for its action.
Dr. Gutti Rao
Dr. Gutti Rao
Thank
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