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What's the pathogenesis for severe stress causing gastritis?
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Dr. Pamela Pappas
Psychiatry
In brief: Stress gastritis
The stomach lining is protected by a mucous gel layer that's regulated by prostaglandins, nitric oxide, certain proteins, and vagus nerve stimulation.
Normally, stomach acid secreted by the stomach's parietal cells does not erode into this lining. But severe stress may disrupt the neural tone such that the gel layer breaks down -- and then acid reaches, inflames, and destroys the stomach lining.

In brief: Stress gastritis
The stomach lining is protected by a mucous gel layer that's regulated by prostaglandins, nitric oxide, certain proteins, and vagus nerve stimulation.
Normally, stomach acid secreted by the stomach's parietal cells does not erode into this lining. But severe stress may disrupt the neural tone such that the gel layer breaks down -- and then acid reaches, inflames, and destroys the stomach lining.
Dr. Pamela Pappas
Dr. Pamela Pappas
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