Has anyone seen permanent effect of bioalcamid or other face injectable fillers?

Not FDA approved. Easy to inject, hard to remove. A patient from europe had aquamid injected into both cheeks. She developed a foreign body reaction which required an incision and drainage get the material to come out. The hole did not close for several months and required packing. Permanent fillers are appealing because of how long it lasts, but if there is a problem, the permanent filler is not easily removed.