Is a herpes culture better than herpes blood test, or the other way around?

Molecular testing. Molecular testing for HSV has been approved by fda and is expected to be better than culture and antibody testing.
Culture for Dx. A culture determines where a specific lesion is caused by herpes, whereas a blood test determines only whether you've ever been exposed to herpes. To diagnose a lesion, the culture is preferred.

Related Questions

Is it possible for herpes culture and blood test to be wrong? I received negative for both...

Not exactly. It is not so much the blood test is wrong, as it might be too early after infection to show up. Culture only positive if "catches" the organism to grow. There are a couple of types of herpes (hsv1/hsv2) as well. Usual to repeat blood work after 3-6 months if equivocal results. Read more...