2 doctors weighed in:

By what mechanism might an increase in gastrin cause peptic ulcer?

2 doctors weighed in
Dr. Arthur Heller
Internal Medicine - Gastroenterology
1 doctor agrees

In brief: Stimulates acid

Gastrin: a hormone made in pancreas, stimulates acid production; more acid tamps down gastrin production-balancing act.
Lack of acid production from meds, eg ppis (nexium (esomeprazole) etc), stomach problems (atrophic gastritis) , kidney disease will incr gastrin levels. Incr. Gastrin levels from tumors can incr. Stomach acid production, overcome body defenses, and cause ulcers. Most ulcers not from xs acid.

In brief: Stimulates acid

Gastrin: a hormone made in pancreas, stimulates acid production; more acid tamps down gastrin production-balancing act.
Lack of acid production from meds, eg ppis (nexium (esomeprazole) etc), stomach problems (atrophic gastritis) , kidney disease will incr gastrin levels. Incr. Gastrin levels from tumors can incr. Stomach acid production, overcome body defenses, and cause ulcers. Most ulcers not from xs acid.
Dr. Arthur Heller
Dr. Arthur Heller
Thank
Get help from a real doctor now
Dr. Steven Seres
Board Certified,
17 years in practice
497K people helped
Continue
108,000 doctors available
Read more answers from doctors