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Is there a difference between epinephrine and norepinephrine?

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Dr. Pamela Pappas
Psychiatry

In brief: Synthesis & Locale

Norepinephrine (ne) and Epinephrine (e) are both sympathomimetic catecholamines that are synthesized in the adrenal medulla and terminals of sympathetic neurons.
Along the metabolic pathway, ne is synthesized first -- and when an enzyme adds a methyl group, you have epinephrine. Ne is the main catecholamine in peripheral tissue and sympathetic neurons. E is mostly made in the adrenal medulla.

In brief: Synthesis & Locale

Norepinephrine (ne) and Epinephrine (e) are both sympathomimetic catecholamines that are synthesized in the adrenal medulla and terminals of sympathetic neurons.
Along the metabolic pathway, ne is synthesized first -- and when an enzyme adds a methyl group, you have epinephrine. Ne is the main catecholamine in peripheral tissue and sympathetic neurons. E is mostly made in the adrenal medulla.
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