How long does it take for the side effects of sertraline (zoloft) to go away?

Days to weeks. I generally advise patients if they have side effects to give it a few days up to a week to see if it will subside. Of course this depends on the side effects. The most common with zoloft (sertraline) and meds in it's class is gastrointestinal. So if a person has terrible diarrhea, they may not be able to last more than a day or two before they need to stop the drug. Also, dry mouth tends to stay.