Effective! Most of my colleagues do not use tetracyclines, but in two\large studues conducted in europe and by the acr in the usa, it was quite effective. Dr. O'dell, president of the acr believes Doxycycline to be more effective, and I agree. I start all patients on one of these two drugs wirth mtx, because of safety and cost.
It works for some. Minocycline and Doxycycline have been shown by eular (multi-unversity), and the nih in the us. Most rheumatologists do not use these, even though there are controlled trials demonstrating equal effececy with Plaquenil (hydroxychloroquine) and sulfasalzine. I use both quite often.
In some cases. Minocin (minocycline) can help some people with rheumatoid arthritis. Even though it is an antibiotic its effect in arthritis is felt to be due to its anti-inflammatory effects and interferring with substances that cause joint and cartilage damage called metalloproteinases.
Medications. Biologic medications such as tnf inhibitors, orencia, (abatacept) actemra, and Rituxan in combination with Methotrexate offer the best results.
Pain/ stiffness. Stiffness of the hands and feet is most common. There is varying degrees of pain and swelling of the small joints of the hands and wrists. Deformities of the hands are common after some years as this disease destroys the joint cartilages due to ongoing inflammation.
Stiffness and pain. The most common first sign of rheumatoid arthritis is morning stiffness lasting an hour or more. This is usually followed by symmetrical joint swelling and pain especially in the small joints (knuckles) of the hands and the toe joints.
Tender warm & stiff. Swollen joints. Morning stiffness that may last for hours, firm bumps of tissue under the skin on your arms (rheumatoid nodules). Fatigue, fever and weight loss rheumatoid arthritis signs and symptoms may vary in severity and may even come and go. Periods of increased disease activity, called flares, alternate with periods of relative remission. Deformity of the joints especaily the hand and feet.