What OTC medication would help me feel better with my depression?

Evaluation first. Medication may or may not be what you need, so please get a psychiatric evaluation of yourself and your depression first. It's important to understand the issues contributing to your depression before dosing up with anything. Exercise and healthy whole-foods diet can do a lot; so can meaningful relationships. Otc, people try st. John's wort, sam-e, or rhodiola for mild to moderate symptoms.