3 doctors weighed in:

Difference between benefits and side effects of cymbalta (duloxetine) and zoloft?

3 doctors weighed in
Dr. John Moranville
Psychiatry
2 doctors agree

In brief: SNRI vs SSRI

Cymbalta (duloxetine) increases serotonin and norepinephrine levels, zoloft increases serotonin levels only.
Cymbala may help chronic pain as well as depression. Both are good antidepressants and have similar side effect profiles. Keep in mind there is no 1antidepressant that is effective for everyone. It may take several trials to find the right one for you or you may be lucky and respond to the 1st one.

In brief: SNRI vs SSRI

Cymbalta (duloxetine) increases serotonin and norepinephrine levels, zoloft increases serotonin levels only.
Cymbala may help chronic pain as well as depression. Both are good antidepressants and have similar side effect profiles. Keep in mind there is no 1antidepressant that is effective for everyone. It may take several trials to find the right one for you or you may be lucky and respond to the 1st one.
Dr. John Moranville
Dr. John Moranville
Thank
Get help from a real doctor now
Dr. Bennett Machanic
Board Certified, Neurology
48 years in practice
55M people helped
Continue
108,000 doctors available
Read more answers from doctors