7 doctors weighed in:
7yrs on prednisone & methotrexate + for "resistant ra" recent elevated jo1, histone, muscle pain. How to confirm if polymyositis w/o stopping meds?
7 doctors weighed in

Dr. Amit Golding
Internal Medicine - Rheumatology
3 doctors agree
In brief: Mucle testing
Inflammatory myopathy, including polymyositis, is best diagnosed and treated by a trained rheumatologist.
Symptoms are proximal muscle weakness. Abnormal lab tests include elevated muscle enzymes (CPK, AST/ALT); positive antibody tests, including Jo-1; abnormal EMG/nerve conduction test; edema seen on an MRI of proximal muscles; muscle biopsy showing destruction and regeneration of muscle cells.

In brief: Mucle testing
Inflammatory myopathy, including polymyositis, is best diagnosed and treated by a trained rheumatologist.
Symptoms are proximal muscle weakness. Abnormal lab tests include elevated muscle enzymes (CPK, AST/ALT); positive antibody tests, including Jo-1; abnormal EMG/nerve conduction test; edema seen on an MRI of proximal muscles; muscle biopsy showing destruction and regeneration of muscle cells.
Dr. Amit Golding
Dr. Amit Golding
Thank
Dr. PHILIP WALLER
Internal Medicine - Rheumatology
1 doctor agrees
In brief: See below
The diagnosis of polymyositis would be based iniatilly on the presence of weakness paricularly proximal muscles.
The next step would be to check blood tests for muscle inflammation including a CPK and aldolase. If thoes are abnormal the next step is a nerve and muscle test called an emg/ncv. If that is abnormal the most definitive test is a muscle biopsy so a jo-1 would not make the diagnosis.

In brief: See below
The diagnosis of polymyositis would be based iniatilly on the presence of weakness paricularly proximal muscles.
The next step would be to check blood tests for muscle inflammation including a CPK and aldolase. If thoes are abnormal the next step is a nerve and muscle test called an emg/ncv. If that is abnormal the most definitive test is a muscle biopsy so a jo-1 would not make the diagnosis.
Dr. PHILIP WALLER
Dr. PHILIP WALLER
Thank
Dr. Thomas Namey
Internal Medicine - Rheumatology
In brief: Both drugs work both
Both drugs are effective in polymyositis.
Your jo-1 could be specious so you need evidence for muscle inflammation.A serum CPK and myoglobin would best reflect the activity of a "myositis, " should one exist. Also, if you have ra, your ccp antibody is positive 98% of the trime. Finally, some patients have two diseases, always a possibility.

In brief: Both drugs work both
Both drugs are effective in polymyositis.
Your jo-1 could be specious so you need evidence for muscle inflammation.A serum CPK and myoglobin would best reflect the activity of a "myositis, " should one exist. Also, if you have ra, your ccp antibody is positive 98% of the trime. Finally, some patients have two diseases, always a possibility.
Dr. Thomas Namey
Dr. Thomas Namey
Thank
Get help from a real doctor now
Dr. Peter Kurzweil
Board Certified, Internal Medicine
46 years in practice
16M people helped
Continue
107,000 doctors available
Read more answers from doctors