Mono or Polyclonal. High levels of immunoglobulins (hypergammaglobulinemia) can be monoclonal (specific) - due to malignant proliferation of plasma cells or lymphocytes as in myeloma or waldenstrom's macroglobulinemia. Polyclonal (many types) hypergammaglobulinemia is a benign condition due to infection, inflammation causing non-specific gamma globulin production such as in hepatitis, immune and allergic disorders.
Hypergammaglobulinem. Hypergammaglobulinemia can be monoclonal (precancerous or cancerous) or polyclonal. Causes of monoclonal hypergammaglobulinemia include multiple myeloma and waldenstrom's macroglobulinemia. Causes of polyclonal hypergammaglobulinemia include aids, rheumatoid arthritis, liver disease, and tuberculosis. For the correct diagnosis you will need to see your doctor.