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Causes of hypergammaglobulinemia?

3 doctors weighed in
Dr. Romeo Mandanas
Internal Medicine - Hematology & Oncology
1 doctor agrees

In brief: Mono or Polyclonal

High levels of immunoglobulins (hypergammaglobulinemia) can be monoclonal (specific) - due to malignant proliferation of plasma cells or lymphocytes as in myeloma or waldenstrom's macroglobulinemia.
Polyclonal (many types) hypergammaglobulinemia is a benign condition due to infection, inflammation causing non-specific gamma globulin production such as in hepatitis, immune and allergic disorders.

In brief: Mono or Polyclonal

High levels of immunoglobulins (hypergammaglobulinemia) can be monoclonal (specific) - due to malignant proliferation of plasma cells or lymphocytes as in myeloma or waldenstrom's macroglobulinemia.
Polyclonal (many types) hypergammaglobulinemia is a benign condition due to infection, inflammation causing non-specific gamma globulin production such as in hepatitis, immune and allergic disorders.
Dr. Romeo Mandanas
Dr. Romeo Mandanas
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Dr. Kelty Baker
Internal Medicine - Hematology

In brief: Hypergammaglobulinem

Hypergammaglobulinemia can be monoclonal (precancerous or cancerous) or polyclonal.
Causes of monoclonal hypergammaglobulinemia include multiple myeloma and waldenstrom's macroglobulinemia. Causes of polyclonal hypergammaglobulinemia include aids, rheumatoid arthritis, liver disease, and tuberculosis. For the correct diagnosis you will need to see your doctor.

In brief: Hypergammaglobulinem

Hypergammaglobulinemia can be monoclonal (precancerous or cancerous) or polyclonal.
Causes of monoclonal hypergammaglobulinemia include multiple myeloma and waldenstrom's macroglobulinemia. Causes of polyclonal hypergammaglobulinemia include aids, rheumatoid arthritis, liver disease, and tuberculosis. For the correct diagnosis you will need to see your doctor.
Dr. Kelty Baker
Dr. Kelty Baker
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