Mono or Polyclonal
High levels of immunoglobulins (hypergammaglobulinemia) can be monoclonal (specific) - due to malignant proliferation of plasma cells or lymphocytes as in myeloma or waldenstrom's macroglobulinemia.
Polyclonal (many types) hypergammaglobulinemia is a benign condition due to infection, inflammation
causing non-specific gamma globulin production such as in hepatitis
, immune and allergic disorders.