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How do vasoconstrictors relieve a headache?
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In brief: Relief of dilation
Migraine headaches are due to nerve excitation which can be triggered by hormones, certain foods, or stress.
This results in a cascade of neurostransmitter release resulting in pulsatile dilation of blood vessels in the brain. A vasoconstrictor medication like the triptans or ergotamine can result in relief of the headache.

In brief: Relief of dilation
Migraine headaches are due to nerve excitation which can be triggered by hormones, certain foods, or stress.
This results in a cascade of neurostransmitter release resulting in pulsatile dilation of blood vessels in the brain. A vasoconstrictor medication like the triptans or ergotamine can result in relief of the headache.
Dr. Katherine Sutherland
Dr. Katherine Sutherland
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