Really worried, jumbled speech, confusion. Could they be due to depression?

Get evaluated. Are these new symptoms or something you've experienced before? Did you start taking any new meds? In any case, these symptoms are too broad to give you a definitive answer. Contact your primary care doctor, get evaluated to rule out anything physical going on.
Possibly. It's possible, but the jumbled speech and confusion could also indicate other things. Please see your doctor very soon -- this would be the safest thing. You should have certain medical labs checked also, which your primary care doctor can get started. Then, a consultation with a psychiatrist might be in order, to review things with you from another perspective.