3 doctors weighed in:
What is the chemical difference between duloxetine and fluoxetine?
3 doctors weighed in

Dr. William Holmes
Pediatrics - Psychiatry
2 doctors agree
In brief: Differences
These two medicines share similarities, but they have different chemical structures, leading to different actions on the nervous system. Fluoxetine almost exclusively acts on the neurotransmitter serotonin, while duloxetine has a mixed action on both serotonin and norepinephrine.
This difference will sometimes result in a person doing better with one medicine versus the other.

In brief: Differences
These two medicines share similarities, but they have different chemical structures, leading to different actions on the nervous system. Fluoxetine almost exclusively acts on the neurotransmitter serotonin, while duloxetine has a mixed action on both serotonin and norepinephrine.
This difference will sometimes result in a person doing better with one medicine versus the other.
Dr. William Holmes
Dr. William Holmes
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