2 doctors weighed in:

Is brittle bone disease genetic?

2 doctors weighed in

In brief: Usually

Osteogenesis imperfecta is a disorder of brittle bones.
There is an abnormality in collagen 1 function, and so you are not able to make bones or other connective tissue structures correctly. This is why people often have "blue sclera" because the collagen is abnormal. Most cases are genetic, but a new mutation (not inherited) can be seen (about 35%).

In brief: Usually

Osteogenesis imperfecta is a disorder of brittle bones.
There is an abnormality in collagen 1 function, and so you are not able to make bones or other connective tissue structures correctly. This is why people often have "blue sclera" because the collagen is abnormal. Most cases are genetic, but a new mutation (not inherited) can be seen (about 35%).
Dr. Lester Thompson
Dr. Lester Thompson
Thank
Dr. Gurmukh Singh
Pathology

In brief: Yes

It is an inherited defect in the formation of one type of collagen that is essential for bone formation.

In brief: Yes

It is an inherited defect in the formation of one type of collagen that is essential for bone formation.
Dr. Gurmukh Singh
Dr. Gurmukh Singh
Thank
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