Can scabies infection make you feel run down and anxious? What other physical symptoms could it present?

Just itching. Mostly, scabies just itches. A lot. Any affliction can make you anxious if you worry/obsess about it, but a scabies infestation (yes, it's an infestation, not an infection) gets no deeper than the upper layers of skin, and cannot by itself cause systemic symptoms such as anxiety or malaise.