8 doctors weighed in:
What causes the blue sclera in osteogenesis imperfecta oi?
8 doctors weighed in

Dr. Richard Bensinger
Ophthalmology
4 doctors agree
In brief: Thin sclera
Osteogenesis imperfecta amongst its other problems, produces a thinning of the white outer coat of the eyeball, the sclera.
Because of this the dark inner lining, the uvea, adds its coloration to light striking the thinned sclera and the result is a blue color. The condition does not actually infuse the sclera with blue - it is an optical effect.

In brief: Thin sclera
Osteogenesis imperfecta amongst its other problems, produces a thinning of the white outer coat of the eyeball, the sclera.
Because of this the dark inner lining, the uvea, adds its coloration to light striking the thinned sclera and the result is a blue color. The condition does not actually infuse the sclera with blue - it is an optical effect.
Dr. Richard Bensinger
Dr. Richard Bensinger
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Dr. Glenn Pomerance
Ophthalmology
2 doctors agree
In brief: Uveal "show"
Oi causes a thinning of the sclera, the white coat of the eye.
It allows the blue-gray uveal layer beneath to be visible through the sclera.

In brief: Uveal "show"
Oi causes a thinning of the sclera, the white coat of the eye.
It allows the blue-gray uveal layer beneath to be visible through the sclera.
Dr. Glenn Pomerance
Dr. Glenn Pomerance
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1 doctor agrees
In brief: See below:
The sclera is the white outer coating of the eye and contains mainly collagen.
In oi sufferers(some-not all) due to the collagen deficiency the sclera is thinner and becomes translucent allowing the underlying tissue to show through. Source(s): http://www.Brittlebone.Org/about-osteogenesis-imperfecta.Htm http://www.Thetech.Org/genetics/ask.Php?Id=93.

In brief: See below:
The sclera is the white outer coating of the eye and contains mainly collagen.
In oi sufferers(some-not all) due to the collagen deficiency the sclera is thinner and becomes translucent allowing the underlying tissue to show through. Source(s): http://www.Brittlebone.Org/about-osteogenesis-imperfecta.Htm http://www.Thetech.Org/genetics/ask.Php?Id=93.
Dr. Michael H. T. Sia
Dr. Michael H. T. Sia
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