What causes the blue sclera in osteogenesis imperfecta oi?

Thin sclera. Osteogenesis imperfecta amongst its other problems, produces a thinning of the white outer coat of the eyeball, the sclera. Because of this the dark inner lining, the uvea, adds its coloration to light striking the thinned sclera and the result is a blue color. The condition does not actually infuse the sclera with blue - it is an optical effect.
Uveal "show" Oi causes a thinning of the sclera, the white coat of the eye. It allows the blue-gray uveal layer beneath to be visible through the sclera.
See below: The sclera is the white outer coating of the eye and contains mainly collagen. In oi sufferers(some-not all) due to the collagen deficiency the sclera is thinner and becomes translucent allowing the underlying tissue to show through. Source(s): http://www.Brittlebone.Org/about-osteogenesis-imperfecta.Htm http://www.Thetech.Org/genetics/ask.Php?Id=93.

Related Questions

What can lead to the blue sclera in osteogenesis imperfecta?

It doesn't. Where the sclera is thin, it appears blue from the deoxygenated blood the choroidal blood vessel layter next tot he sclera. This is normal in patients who are nearsighted. Rarely, this is a sign associated with osteogenesis imperfecta. Not a cause. Not diagnostic. Read more...

Why are sclera blue in osteogenesis imperfecta?

Thinner sclera. The white part of the eyeball is the sclera. In osteogenesis imperfecta, the person has a genetic mutation that causes him to make defective connective tissues and/or not enough connective tissues. The eyeball sclera is made of connective tissue, but it is thinner in an o.I. Person, so it looks bluish instead of white. Read more...
Blue sclera. The thinner scleral outer wall allows some transmission of the darker inner color giving a sensation of blue. Read more...

I am 28 & when move my eyes right and left I see ting of blue sclera is it normal or any kind of problem and there is no genetic osteogenesis problm?

Blue Sclera. There are other causes of blue sclera besides osteogenesis imperfecta. Other causes can include: medication effects, topical eye drops, exposure to silver compounds, collagen synthesis disease, and alkaptopuria. It would be best to have this evaluated by an opthomologist. Read more...

I have osteogenesis imperfecta and I'm 8+1 weeks pregnant. Could this be a factor to cause miscarriage? Is this a high risk pregnancy?

Yes. Depending on the type of OI, there are a number of risks to you in pregnancy ranging from heart valve problems, aneurysms to fracture. Because connective tissue is an integral part of creating the various membranes to nurture the fetus, there can be additional risks for miscarriage and impact on fetal development. I would consider this to be a high risk pregnancy. Read more...