All drugs have SE. All prescription & otc drugs have side effects. In fact, all otc supplements, even those labeled natural & organic, have side effects. There is no risk-free drug/supplement. Only take something if potential benefit exceeds potential risk. Check out www. Drugs. Com for drug info. Or try online. Epocrates. Com (but you'll need to register for free). Amlodipine is known for edema.