Does protonix (pantoprazole) cause psoriasis to flare?

Possibly. There are certain medication that are well known to flare psoriasis. The most common ones are beta blockers and lithium. There are many others, but they occur on a much less frequent basis. I would see a dermatologist to find out if the Protonix (pantoprazole) may be causing a flare. More likely, flares are due to stress, smoking, and other things.