Could someone describe what depoprovera shot side effects?

Side Effects. Depo Provera (medroxyprogesterone) actually has a lower failure rate for pregnancy than tubal ligations. But, there are a myriad of side effects. Weight gain is common as is irregular bleeding. There are some women in whom ovulation will be suppressed for prolonged periods of time. In addition, long term use can lead to bone loss and loss of sex drive.