11 doctors weighed in:

How do antidepressant medications work on the brain?

11 doctors weighed in
4 doctors agree

In brief: Addendum

A current working hypothesis is that due to the effects colleagues have discussed, signalling within nerve cella is enhanced.
Therefore when signals from many nerve cells are combined by a receiving cell, its subsequent output response is amplified. (sort of like a digital sound amplifier.) in depression, these output signals are muffled.

In brief: Addendum

A current working hypothesis is that due to the effects colleagues have discussed, signalling within nerve cella is enhanced.
Therefore when signals from many nerve cells are combined by a receiving cell, its subsequent output response is amplified. (sort of like a digital sound amplifier.) in depression, these output signals are muffled.
Dr. Jeffrey Satinover
Dr. Jeffrey Satinover
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Dr. Byron Law-Yone
Psychiatry
4 doctors agree

In brief: Nobody knows.

Nobody knows for sure.
Most antidepressants influence brain neurotransmitters like serotonin, nor Epinephrine and dopamine. These brain messengers have a role in maintaining a normal mood but how they really work remains a mystery. About a third of our patients respond poorly to antidepressants so we need to look for medications that influence other neurobiological systems.

In brief: Nobody knows.

Nobody knows for sure.
Most antidepressants influence brain neurotransmitters like serotonin, nor Epinephrine and dopamine. These brain messengers have a role in maintaining a normal mood but how they really work remains a mystery. About a third of our patients respond poorly to antidepressants so we need to look for medications that influence other neurobiological systems.
Dr. Byron Law-Yone
Dr. Byron Law-Yone
Thank
2 doctors agree

In brief: Neurotransmission

Antidepressant medications act on enzymes, receptors, and neurotransmitters in various parts of the brain to modulate the functioning of circuitry that affects mood, thinking, sleeping, anxiety and the ability to think and concentrate.
Each medication is a bit different, and they are separated into classes depending on their affects on the brain circuits. The results are to normalize functioning.

In brief: Neurotransmission

Antidepressant medications act on enzymes, receptors, and neurotransmitters in various parts of the brain to modulate the functioning of circuitry that affects mood, thinking, sleeping, anxiety and the ability to think and concentrate.
Each medication is a bit different, and they are separated into classes depending on their affects on the brain circuits. The results are to normalize functioning.
Dr. Alan Koenigsberg
Dr. Alan Koenigsberg
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