My doctor just told me she has seen patients go from having tested positive 4 HSV 2 antibodies to negative in their lifetime. Is this possible or no?

Absolutely. These tests are fraught with pitfalls, both in performance and interpretation, and sometimes the antibodies disappear. As a pathologist and laboratory physician, i constantly remind others, "the most helpful test is the history and physical exam." let this, not a lab value, guide your treatment decisions.