10 doctors weighed in:

Is there a genetic component to stomach cancer ?

10 doctors weighed in
Dr. Liawaty Ho
Internal Medicine - Hematology & Oncology
5 doctors agree

In brief: YES, inherited type

There is a familial/inherited type of gastric cancer which is called hereditary diffuse gastric cancer.It is caused by germline mutations in the e-cadherin (cdh1) gene that are inherited in an autosomal dominant pattern.

In brief: YES, inherited type

There is a familial/inherited type of gastric cancer which is called hereditary diffuse gastric cancer.It is caused by germline mutations in the e-cadherin (cdh1) gene that are inherited in an autosomal dominant pattern.
Dr. Liawaty Ho
Dr. Liawaty Ho
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5 doctors agree

In brief: Possibly

There are some asian countries that have higher incidence of gastric cancer, and there is thought to be an association of stomach cancer with smoked foods, excess alcohol, and cigarette smoking.
Lifestyle and possibly asian heritage may be associated, but gastric cancer in the us is fairly uncommon.

In brief: Possibly

There are some asian countries that have higher incidence of gastric cancer, and there is thought to be an association of stomach cancer with smoked foods, excess alcohol, and cigarette smoking.
Lifestyle and possibly asian heritage may be associated, but gastric cancer in the us is fairly uncommon.
Dr. Mark Hoepfner
Dr. Mark Hoepfner
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Dr. Ester Kwok
Internal Medicine
3 doctors agree

In brief: Maybe and yes

When a person is diagnosed with stomach cancer, there appears to be an increased risk of developing stomach cancer in first degree relatives (mother, siblings, children).
And rarely, there are familial genes that are associated with increased risk for stomach cancer, such as peutz jegher syndrome, cowden's syndrome, and recently it was found that brca-2 genes may also carry an increased risk.

In brief: Maybe and yes

When a person is diagnosed with stomach cancer, there appears to be an increased risk of developing stomach cancer in first degree relatives (mother, siblings, children).
And rarely, there are familial genes that are associated with increased risk for stomach cancer, such as peutz jegher syndrome, cowden's syndrome, and recently it was found that brca-2 genes may also carry an increased risk.
Dr. Ester Kwok
Dr. Ester Kwok
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Dr. Joseph Woods
Pathology
2 doctors agree

In brief: Apparently not.

This does not appear to have a genetic component to it, but that dose not mean it does not exist, the most serious factor is infection with helicobacter pylori, and in patients where this was treated, the lesion taken for stomach cancer resolved in many instances.
Diet is also a strong factor, like smoked and salted foods. In <>15% cases, lymphoma is the cause.

In brief: Apparently not.

This does not appear to have a genetic component to it, but that dose not mean it does not exist, the most serious factor is infection with helicobacter pylori, and in patients where this was treated, the lesion taken for stomach cancer resolved in many instances.
Diet is also a strong factor, like smoked and salted foods. In <>15% cases, lymphoma is the cause.
Dr. Joseph Woods
Dr. Joseph Woods
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