11 doctors weighed in:

Can taking a lot of tylenol (acetaminophen) pm cause bi polar moods to be more extreme?

11 doctors weighed in
Dr. Andrew Ho
Psychiatry
5 doctors agree

In brief: Kills liver cells

Worst thing about tylenol (acetaminophen) is that taking as little as 3000 mg per day (6 extra strength pills) can cause fatal liver damage.
Healthy adults who do not drink alcohol might be able to recover but still, this is the biggest risk of fatality for almost any drug currently on the market, let alone something available without prescription. I would worry more about liver than bipolar if taking a lot.

In brief: Kills liver cells

Worst thing about tylenol (acetaminophen) is that taking as little as 3000 mg per day (6 extra strength pills) can cause fatal liver damage.
Healthy adults who do not drink alcohol might be able to recover but still, this is the biggest risk of fatality for almost any drug currently on the market, let alone something available without prescription. I would worry more about liver than bipolar if taking a lot.
Dr. Andrew Ho
Dr. Andrew Ho
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Dr. Carla Enriquez
Pediatrics
4 doctors agree

In brief: Maybe

There are reports that small doses of Diphenhydramine can impact frontal lobe function for days after a single use.
This might impair your judgment particularly if you are taking psychotropic medications or alcohol. Impaired judgment can lead to increased anxiety which in turn can trigger bipolar meltdowns. I'd avoid first generation antihistamines if possible.

In brief: Maybe

There are reports that small doses of Diphenhydramine can impact frontal lobe function for days after a single use.
This might impair your judgment particularly if you are taking psychotropic medications or alcohol. Impaired judgment can lead to increased anxiety which in turn can trigger bipolar meltdowns. I'd avoid first generation antihistamines if possible.
Dr. Carla Enriquez
Dr. Carla Enriquez
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Dr. David Rosenfeld
Pain Management
3 doctors agree

In brief: I doubt it

Extreme reactions can include seizures and arrythmias but I am not aware of it worsening bipolar disorder.

In brief: I doubt it

Extreme reactions can include seizures and arrythmias but I am not aware of it worsening bipolar disorder.
Dr. David Rosenfeld
Dr. David Rosenfeld
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