What's involved in allogeneic stem cell transplantation?

Donor matching. This involves two people: the (healthy) donor and the (patient) recipient. Donors must have a tissue (hla) type that matches the recipient. Matching is performed on three or more loci of the hla gene, and a perfect match at these loci is preferred. Even with this, immunosuppression is often needed due to graft vs host disease.
Chemo +/- radiation. The first part of an allogeneic stem cell transplant involves giving chemotherapy and/or radiation to the patient. Then the stem cells from a donor are infused intravenously. There are many risks and side effects possible with this treatment but it can help cure many diseases.

Related Questions

Refractory ALL in adolescent male 21 years management other than Allogeneic Stem Cell Transplant?

Complex question. only experts in the field, hematologists/oncologists would answer this question after careful review of the case and different options available, I know it might be frustrating at times, but complex condition as ALL need to be managed in specialized hospitals/institutions, it's your right as a patient to have second and even third opinion, but in the end you have to trust the treating team, good luck. Read more...

Why are 2 umbilical cords sometimes used in an allogeneic stem cell transplant?

Remember. Double cord blood transplantations are completed because the number of stem cells in one unit of cord blood is usually not enough to repopulate the bone marrow of adult sized persons. So two helps make sure that the transplant is successful. Hope that helps. . Read more...
Increased stem cells. The rate of engraftment in adults following an umbilical cord blood stem cell transplant (UCBT) is quite slow. This increases risk of infection while the WBC count is low, and requires a longer period of RBC and platelet transfusion support. To speed up the rate of engraftment double UCBT are often used. Early both cord units might produce WBC, but later a single unit predominates. Read more...

What is stem cell transplantation's status in the u.S. Now?

Used non-manipulated. Use of adult mesenchymal stem-stromal cells (mscs) are currently in clinical trial in us/internationally. Trend is toward use of fat derived mscs, havested by liposuction, isolated and concentrated in tissue culture. Early reports suggest significant improvement in neurological, autoimmune and organ functions. Many more mscs in fat than bone marrow making ad-msc the center of most research now. Read more...

Are there stem cell transplantation therapy trials in the u.S.?

Yes. Use of adult mesenchymal stem-stromal cells (mscs) are currently in clinical trial in us/internationally. Trend is toward use of fat derived mscs, havested by liposuction, isolated and concentrated in tissue culture. Early reports suggest significant improvement in neurological, autoimmune and organ functions. Many more mscs in fat than bone marrow making ad-msc the center of most research now. Read more...

What kind of stem cell transplant is the most common?

Bone marrow. At some institutions stem cells, or stem like cells are isolated and enriched for bone marrow transplantation. This is done most commonly for hematologic malignancies such as leukemia. Read more...
Blood stem cells. Stem cell transplants using blood stem cells for conditions such as leukemias and other cancers are the most common stem cell transplants. These transplants use stem cells from the blood or bone marrow. Read more...

Stem cell transplant in latin america possible?

Hospital Angeles. A wide variety of studies utilizing stem cells are being conducted at hospital angeles in tijuana, mexico. I believe this is also the only jhaco approved hospital in mexico. Read more...

For leukemia has anyone had a successful stem cell transplant?

Many. There are different types of leukemia, lymphoid vs myeloid, acute vs chronic. Some leukemia can be treated for chemotherapy only, some leukemia will need to be treated by stem cell transplant. The outcome of stem cell transplant is different depending on what type of leukemia a patient has. However, stem cell transplant has an established record to cure leukemia. Read more...