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What are germline gene alterations?

4 doctors weighed in
Dr. Scott Adams
Pediatrics - Hematology & Oncology
3 doctors agree

In brief: Inheritable

"germline" refers to genes that are present in every cell of the body from conception or shortly afterwards, including sperm/ ova, and thus can be passed down to offspring.
This term is used to distinguish these types of inherited genetic mutations from those that are not inherited - not present in the dna of sperm or ova.

In brief: Inheritable

"germline" refers to genes that are present in every cell of the body from conception or shortly afterwards, including sperm/ ova, and thus can be passed down to offspring.
This term is used to distinguish these types of inherited genetic mutations from those that are not inherited - not present in the dna of sperm or ova.
Dr. Scott Adams
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