3 doctors weighed in:

Read this in wikipedia: "when a cell s telomeres shorten to critical lengths, the cell senesces" is that how we age?

3 doctors weighed in
Dr. Theresa Redling
Internal Medicine - Geriatrics
1 doctor agrees

In brief: One theory

This one biomarker of aging.
Other theories include oxidative stress, and other environmental stressors, genetics, etc. Nature(genetic longevity) and nurture(environmental, how we treat ourselves, medical care) all contribute to the longevity of the human race.

In brief: One theory

This one biomarker of aging.
Other theories include oxidative stress, and other environmental stressors, genetics, etc. Nature(genetic longevity) and nurture(environmental, how we treat ourselves, medical care) all contribute to the longevity of the human race.
Dr. Theresa Redling
Dr. Theresa Redling
Thank
Dr. Ed Friedlander
Pathology

In brief: Basically no

This is simplistic and doesn't fit the facts, though it may be taught as "fact" in some classrooms.
The cells that bear the brunt of aging (neurons, fibroblasts) almost never divide. Mice age but don't have telomere shortening. It may be a factor in some of our cell populations (i suspect in epidermis) but it's not the magic secret any more than free radicals were a while back.

In brief: Basically no

This is simplistic and doesn't fit the facts, though it may be taught as "fact" in some classrooms.
The cells that bear the brunt of aging (neurons, fibroblasts) almost never divide. Mice age but don't have telomere shortening. It may be a factor in some of our cell populations (i suspect in epidermis) but it's not the magic secret any more than free radicals were a while back.
Dr. Ed Friedlander
Dr. Ed Friedlander
Thank
1 comment
Dr. Ed Friedlander
"Cell senescence" is actually about the loss of the cell's ability to divide in cell culture -- the Hayflick phenomenon. This is related to telomeres shortening to the point of real genes becoming damaged and the cell's genetic monitors telling it to stop dividing.
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