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How does an extra chromosome set cause big problems for the baby?

1 doctor weighed in
Dr. Nikolaos Zacharias
Obstetrics & Gynecology - Maternal Fetal Medicine

In brief: Multiorgan effects.

Aneuploidy (i.e. One extra or missing chromosome) is a group of major genetic disorders that can affect all organ systems, more commonly the heart, brain and kidneys.
Examples include down syndrome (mongolism) and edwards' syndrome (usually lethal). The exact mechanism by which the chromosomal aberrration leads to these effects is not entirely clear but may have to do with gene silencing.

In brief: Multiorgan effects.

Aneuploidy (i.e. One extra or missing chromosome) is a group of major genetic disorders that can affect all organ systems, more commonly the heart, brain and kidneys.
Examples include down syndrome (mongolism) and edwards' syndrome (usually lethal). The exact mechanism by which the chromosomal aberrration leads to these effects is not entirely clear but may have to do with gene silencing.
Dr. Nikolaos Zacharias
Dr. Nikolaos Zacharias
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