2 doctors weighed in:
How many single gene disorders are there?
2 doctors weighed in

Dr. Andrew Turrisi
Radiation Oncology
1 doctor agrees
In brief: The notable
Bcr-abl is a single translocated change in chrinic myelogenous leukemia.
The target drug (imatinib, gleevec) controls the mutation, and the disease. Gi stromal tumors, gist, has c-kit managed by the same drug, but resistance occurs. Common cancers are poly-mutated genes. Even brca-1 =2 mutation convey risk in breast and ovarian cancer, not just one gene= cancer.

In brief: The notable
Bcr-abl is a single translocated change in chrinic myelogenous leukemia.
The target drug (imatinib, gleevec) controls the mutation, and the disease. Gi stromal tumors, gist, has c-kit managed by the same drug, but resistance occurs. Common cancers are poly-mutated genes. Even brca-1 =2 mutation convey risk in breast and ovarian cancer, not just one gene= cancer.
Dr. Andrew Turrisi
Dr. Andrew Turrisi
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