Regressed developmen. The hallmark is a developmental regression usually starting in the first 2 years. This is associated with loss of visuion.
Many. The clinical features include small hands and feet and a deceleration of the rate of head growth (including microcephaly in some). Repetitive stereotyped hand movements, such as wringing and/or repeatedly putting hands into the mouth, are also noted. people with rett syndrome are prone to gastrointestinal disorders and up to 80% have seizures. they typically have no verbal skills.