50% are asymptomatic. About half of patients with chronic leukemia have no symptoms and are discovered on a routine CBC (complete blood count) usually obtained for some other reason. When symptoms do occur, they may include fatigue or tiredness, swollen glands or lymph nodes, low grade fever or sweats that are persistent. More advanced symptoms can include, bleeding, bruising, anemia, enlarging belly or an infection.
Varies. The patient could have no symptoms at all and only be picked up from routine blood tests. On the other hand, they may have lymph nodes that have gotten bigger, anemia, fatigue, fevers, weigh loss, infections, large spleen, etc.
Many. Swolen lymph nodes, fever, weight loss, fatigue, night sweat, poor apetite, then other issues depending on the complications due to cll.
Fatigue. Fatigue is the most common symptom. Examination may show an enlarged spleen. The diagnosis is suspected by blood testing and confirmed by bone marrow biopsy.
Varies. Majority cases are asymptomatic and the evaluation is started due to abnormal blood work. When the leukemia is more advanced - patient can become symptomatic-and can be presented with-anemia, low platelet level- bleeding, increase white blood counts, recurrent infections, fatigue/decrease energy level, fever/chils/night sweats, increase abdominal girth etc. Read more : www. Cancer. Net / www. Lls. Org.
Blood work etc. You would need at least- blood work. Imaging scan for abdomen would be needed in certain chronic leukemia (cml) to evaluate spleen or if there is other indication (such as presence of abdominal pain etc); a bone marrow biopsy will be needed in certain case of chronic leukemia. Please discuss further in detail with your hematologist/ oncologist. Read more at www. Cancer. Net ; www. Lls. Org.
FCM. Flowcytometry from a blood sample is the standard test to diagnose chronic lymphocytic leukemia. Chronic mylogenous leukemia can also be diagnosed from a blood test looking for bcr-abl mutation by pcr or fish. Other important tests include a conventional karyotyping and cytogenetics to determine prognosis. Karyotyping and cytogenetucs are usually done from bone marrow in cml.
Usually sporadic. CML is associated with a known genetic abnormality (t (9;22) - otherwise known as the philadelphia chromosome). It is not known what in the environment 'causes' this. Chronic lymphocytic leukemia has different common genetic changes, the causes of which also are not known. Rarely though, cll seems to run in families. This has led to significant research into what genetic drivers may be found.
Wish I knew. There is some evidence that excessive exposure to chemicals such as benzene may lead to an increased incidence of chronic myeloid leukemia, and excessive exposure to radiation has also been implicated. Cllhas been linked to pesticide exposure in some-but not all-studies. In animals, diseases like cll are usually caused by a virus. In practice a doctor rarely finds the cause of a patients leukemia.
Visit med onc doctor. The best approach is to meet with a medical oncologist with experience and discuss the treatment options when the diagnosis is confirmed. There are specifical mutations that can be tested for to guide the therapy. It depends if you have CLL or CML type. The oncologist can order the genetic testing and discuss current treatment guidelines. Then you give treatment a shot and see how it works.
Chonic leukemia. Chronic leukemia in general can be divided in to chronic lymphocyic leukemia (cll) or chronic myelogenous leukemia (cml). Boh are usually in adult. Median age a diagnosis in CML is 50 yrs; and in cll is 70 yrs. Cll accounts for 30% leukemia case -which is the most common leukemia in western countries. CML accounts for 15-20% cases. Most common presentation for both are abnormal blood test.
Blood cancer. Leukemia is a cancer of the white blood cells and bone marrow is the site of the defect. Treatment and outcome depend on the type of leukemia and stage of the disease. Some leukemias may be curable with intensive therapy and may require bone marrow transplantation.
Depends on type. Treatment will depend on type of chronic leukemia--cml vs cll. For cll, the treatment will be indicated only if symptomatic or there is indication to treat. Asymptomatic will be put on observation only. CML is associated with a bcr-abl fusion gene abnormality. Treatment is a pill - which is a tyrosine kinase inhibitor that specifically targeted to the abnormal bcr-abl fusion gene.
See doctor. Leukemia is not some thing you can treat yourself for. See your doctor.