What are the major presenting symptoms of smallpox?

Smallpox. has approx. 12 day incubation period. Fever is usually 101° F or >. Sx's include: headache, muscle pain, malaise, nausea, vomiting, back pain, Rash develops into pustules on forehead & then involves face. Lesions than occur closest to the trunk on extremities on the track and later to the distal extremities. .
Infected pustules. Fortunately we do not have to deal with this any more unless some terrorist gets into a lab and steals one of the few remaining repositories. The disease starts with headache, rapid onset of fever and the development of infected pustules throughout the skin.