Varies. Majority cases are asymptomatic and the evaluation is started due to abnormal blood work. When the leukemia is more advanced - patient can become symptomatic-and can be presented with-anemia, low platelet level- bleeding, increase white blood counts, recurrent infections, fatigue/decrease energy level, fever/chils/night sweats, increase abdominal girth etc. Read more : www. Cancer. Net / www. Lls. Org.