5 doctors weighed in:
My mom (75 years old but biologically younger) has early parkinson's. Any downside to mao-b inhibitor instead of levodopa if symptoms minimal?
5 doctors weighed in

Dr. Robert Kwok
Pediatrics
3 doctors agree
In brief: Neurologist can help
A small amount of information is on the internet regarding MAO inhibitors (such as selegiline) and l-dopa to treat parkinson's.
Among elderly patients, individuals can react quite differently to various meds & doses, so a person's treatment has to be customized. It appears that using both meds allows one to use a lower dose of l-dopa. The list of selegiline side effects looks milder than l-dopa's.

In brief: Neurologist can help
A small amount of information is on the internet regarding MAO inhibitors (such as selegiline) and l-dopa to treat parkinson's.
Among elderly patients, individuals can react quite differently to various meds & doses, so a person's treatment has to be customized. It appears that using both meds allows one to use a lower dose of l-dopa. The list of selegiline side effects looks milder than l-dopa's.
Dr. Robert Kwok
Dr. Robert Kwok
Thank
In brief: NO, it's preferred!!
Dopamine meds are mainstay of treatment.
Modern therapy recommends longer lasting, milder potency meds first: Azilect (mao-b selective inhibitor) & Dopamine agonists (requip xl/mirapex er/neupro). After they've been maximized & stronger meds ate needed to adequately manage symptoms, then sinemet +/- Comtan (stalevo (carbidopa and levodopa and entacapone) is both together) are begun. Tailor rx with side effects in mind for each person.

In brief: NO, it's preferred!!
Dopamine meds are mainstay of treatment.
Modern therapy recommends longer lasting, milder potency meds first: Azilect (mao-b selective inhibitor) & Dopamine agonists (requip xl/mirapex er/neupro). After they've been maximized & stronger meds ate needed to adequately manage symptoms, then sinemet +/- Comtan (stalevo (carbidopa and levodopa and entacapone) is both together) are begun. Tailor rx with side effects in mind for each person.
Dr. Robert Hutchman
Dr. Robert Hutchman
Thank
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