3 doctors weighed in:

Why does the drug vincristine have side effects?

3 doctors weighed in
Dr. Andrew Turrisi
Radiation Oncology
1 doctor agrees

In brief: It's chief toxicity

Is neuropathy; it is not myelosuppressive.
It suppresses the mitotic spindles made up of fibrillary structural piees siilar tto those that make up axons, nerves. Usually distal numbness and tingling of hands and feet. It is easy to blend with other drugs because its toxicty does not overlap with theirs.

In brief: It's chief toxicity

Is neuropathy; it is not myelosuppressive.
It suppresses the mitotic spindles made up of fibrillary structural piees siilar tto those that make up axons, nerves. Usually distal numbness and tingling of hands and feet. It is easy to blend with other drugs because its toxicty does not overlap with theirs.
Dr. Andrew Turrisi
Dr. Andrew Turrisi
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Dr. Michael Engel
Pediatrics - Hematology & Oncology

In brief: Vincristine ...

Blocks cell cycle progression.
Vincristine is a vinca alkaloid originally purified from periwinkle. It binds tubulin and prevents microtubule elongation. Thus, it blocks the mitotic spindle and causes mitotic arrest in dividing cells. Its primary side effects are neuropathic in nature, a reflection of the important structural role played by microtubules in neuronal projections, particularly axons.

In brief: Vincristine ...

Blocks cell cycle progression.
Vincristine is a vinca alkaloid originally purified from periwinkle. It binds tubulin and prevents microtubule elongation. Thus, it blocks the mitotic spindle and causes mitotic arrest in dividing cells. Its primary side effects are neuropathic in nature, a reflection of the important structural role played by microtubules in neuronal projections, particularly axons.
Dr. Michael Engel
Dr. Michael Engel
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