3 doctors weighed in:

Which is more prefered vincristine or vinblastin sulfate?

3 doctors weighed in
Dr. Andrew Turrisi
Radiation Oncology
1 doctor agrees

In brief: They are in the same

Class but not interchangeable.
Vcr is used in many pediatric diseases in combination. It causes constipation in that age group. It used to be used in brca (cmf-vp) and many adult lymphoma. Vbl is used in hd, testis cancer as part of curative regimens. It is also used as a single agent in lung and breast for symptom relief.

In brief: They are in the same

Class but not interchangeable.
Vcr is used in many pediatric diseases in combination. It causes constipation in that age group. It used to be used in brca (cmf-vp) and many adult lymphoma. Vbl is used in hd, testis cancer as part of curative regimens. It is also used as a single agent in lung and breast for symptom relief.
Dr. Andrew Turrisi
Dr. Andrew Turrisi
Thank
Dr. Michael Engel
Pediatrics - Hematology & Oncology

In brief: Periwinkle gave us..

These drugs, both vinca alkaloids.
But they are not the same and are used for different indications. Neither is used in monotherapy in modern chemo therapeutic regimens. Vinblastine has myelosuppressive features, while vincristine has very little effect on circulating counts. In addition to its cancer rx role, vinblastine is a core element of first line treatment for langerhans cell histiocytosis.

In brief: Periwinkle gave us..

These drugs, both vinca alkaloids.
But they are not the same and are used for different indications. Neither is used in monotherapy in modern chemo therapeutic regimens. Vinblastine has myelosuppressive features, while vincristine has very little effect on circulating counts. In addition to its cancer rx role, vinblastine is a core element of first line treatment for langerhans cell histiocytosis.
Dr. Michael Engel
Dr. Michael Engel
Thank
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