I started penicillin yesterday for strep throat with acetaminophen. Last night I woke up 4 times with severe night sweats. IS this normal?

Strep throat. Yes, its normal. Can take a few days to see improvement with the symptoms. If no improvement in 72 hrs then follow up with your doc.
Not unusual. You may take several days to appreciate an improvement in your general symptoms, but this is not unusual.

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